Yes, Fildena 100 can be taken with or without food. However, taking it with a heavy meal may delay the onset of action. It is recommended to take Fildena 100 on an empty stomach or with a light meal to experience faster and more effective results. Additionally, avoid consuming grapefruit or grapefruit juice while taking Fildena 100 as it can interact negatively with the medication. Always consult with a healthcare professional before starting any new medication to ensure it is safe and appropriate for you based on your individual health profile and any existing medical conditions you may have.